A. Results on HEIRO™ documented at the State of Pennsylvania Animal Diagnostic Laboratory System (PADLS) on January 11, 2008. All electrolyte/mineral levels reported as SAFE. Actual levels of these important elements in HEIRO™ as follows:

		Date Submitted: 1-11-08 Report Date:      1-17-08
	HEIRO™	Laboratory Maximum Tolerance Level Index of Animal Health
ppm Calcium	4,950 - Safe	20,000
ppm Colbalt	.246 - Safe	25
ppm Copper	5.05 - Safe	250
ppm Iron	154 - Safe	500
ppm Magnesium	883 - Safe	8,000
ppm Phosphorus	1,085 - Safe	10,000
ppm Potassium	5,190 - Safe	10,000
ppm Selenium	2.43 - Safe	5
ppm Sodium	2,910 - Safe	N/A
ppm Zinc	25.5 - Safe	500

As shown, USDA Certified organic herbs are a safe, natural, and powerful source of minerals/electrolytes.

B.   Equi-Analytical Laboratories - the top commercial feed testing lab in the country. Results show low sugar (ESC) and low starch so it is SAFE. Results show a protein level of grass hay and a non-fiber carbohydrate (NFC) in the normal range of beet pulp. Results show a HUGE Vitamin E amount that comes to 3,100-3,200 units of Vitamin E in just one tablespoon a day. That is, by far, the best level of any supplement. The results confirm the significant levels of ten (10) electrolytes and minerals.

HEIRO™ has been tested extensively for safety, content, and proven results.

			Date Submitted: 1/9/08 Date Reported:  1/18/08
% Moisture		10.6
% Dry Matter		89.4
	As Sampled		Dry Matter
Digestible Energy (DE), Mcal/lb		1.38		1.54
	%	g/lb.	%	g/lb.
Crude Protein	11.3	51.1	12.6	57.1
Acid Detergent Fiber (ADF)	11.0	50.1	12.4	56.0
Neutral Detergent Fiber (NDF)	18.4	83.3	20.5	93.1
ESC (Simple Sugars)	2.2	10.0	2.5	11.1
Starch	1.3	5.7	1.4	6.3
Non Fiber Carb. (NFC)	51.2	232.3	57.3	259.8
	%	g/lb.	%	g/lb.
Calcium	.61	2.75	.68	3.08
Phosphorus	.17	.75	.19	.84
Magnesium	.10	.44	.11	.49
Potassium	.45	2.02	.50	2.26
Sodium	.317	1.436	.354	1.606
	ppm	mg/lb.	ppm	mg/lb.
Iron	159	72	178	81
Zinc	36	16	40	18
Copper	6	3	6	3
Manganese	25	11	28	13
Molybdenum	1.68	.76	1.87	.85
	As Fed		100% Dry
Vitamin E, IU/Lb.	137,000		153,210

III.   What Is Not In HEIRO™?

1. HEIRO™ is not cooked or processed - at times you will actually see the entire seed of the herb in HEIRO™. Cooking takes vitamins/minerals out.
2. Unsafe amounts of unknown items - HEIRO's™ herbs are USDA Certified organic and double-lab tested for content and safety. In 2000, the State of California Department of Health Services put out a warning that five (5) Chinese herbal mixtures for Diabetes contained two (2) pharmaceutical drugs. Vet. Practice News, May 2006.
3. No fillers - this is why you only give one (1) tablespoon a day.
4. Not a diluted tea - again, vitamins and minerals are lost.
5. No sugar additives - HEIRO™ is the only supplement tested to be low in sugar and starch. Our starch is only 1.3% and our simple sugar is only 2.2%.

IV. What are the signs of Insulin Resistance?

1.   Laminitis – acute or chronic.  Repeat episodes over the years, pasture turnout stopped but still happens, secondary to Cushings disease, more often in ponies, occurs in the middle of the winter when there is no grass around. The horse only gets hay and no grain and still happens.
2.   Overweight – either by diet, lack of exercise, or genetics.  25% of people with Insulin Resistance due to genetics.  On no grain or little grain and stays big, exercise and still big. Cresty neck often seen.
3.   Cushings – 2 ways Insulin Resistance is linked with Cushings.

a.   Many with diagnosed Cushings also have Insulin Resistance but this second condition is not diagnosed, so on Pergolide but still does not do well.
b.   Recent study shows Cushings in horses massively under diagnosed, so if these are missed, then more are missed with both Cushings and Insulin Resistance.

4.   Age – as horses get older, they lose muscle and gain fat.  Fat production goes way up in Insulin Resistance because Insulin makes fat and fat produces toxins leading to an increase in Insulin. Also as horses age, Cushings incidence goes up.
5.   Fatigue – can not exercise as well as in the past.  They become dull and resist riders.
6. Certain Breeds- Breeds that were designed for a rugged existence seem to be more susceptible due to today's easier surroundings. These breeds include Quarter Horses, Morgans, Paso Finos, Mustangs, Pony breeds, Tennessee Walkers, Rocky Mountain Horses.

V.      What Is Insulin Resistance?

1.   Abnormally high Insulin levels cause metabolic changes leading to increased fat, overweight, fatigue, and eventually Laminitis.
 2.   Why high Insulin?  Inability to respond and use Insulin the body produces because the Insulin is not functioning properly; higher and higher Insulin levels are needed to achieve the same effect.  These high levels of Insulin damage the body.

VI.    Why Laminitis in Insulin Resistance?
          Several ways:

1.   Insulin itself – at high levels can damage vessels.  A recent Australian study showed that giving a horse a shot of Insulin causes profound Laminitis clinically and microscopically. K. Asplin, Australian Government Rural Industries Research, November 2007.
2.  A University of Kentucky study shows that inflammatory proteins elevate when the horse has Insulin Resistance and this irritates blood vessels leading to blood flow disruption to feet. A. Adams, J. An. Sci., 2007, Vol. 85.
3.  Extreme cases – if hyperglycemic, can irritate blood vessels.
4.  First time considered as a possible cause of Laminitis by Dr. Reilly – Foot Neuropathy. In diabetic people, nerves to feet become desensitized – if in a horse, could have Laminitis but not know of damage as readily.  If the horse shows no pain, Laminitis spreads until critical.  We do not get a warning.  Why a possible?  70,000 foot amputations a year in the USA of Insulin Resistance/Diabetic people.
5.   Overweight – all these problems compounded by the stress of high weight.

VII.    How to Test?  Testing procedures are discussed in depth in our Insulin Resistance-HEIRO™ Article. 

For further information, go to Insulin Resistance-HEIRO™ in the Article section for the following:
What is Insulin?; Insulin Resistance Defined; Exercise needed and why; Chromium, Magnesium, Pergolide & Thyroid Powder Information; Diet to feed; Good and Back Snacks; How to correctly test for Insulin; Glucose-Insulin Ratios: Results looking to diagnose; How to Vaccinate; Farrier Care; Specific supplements like beet pulp and rice bran; X-rays; Which low carbo feeds are the best.

For the 2008 updated information, please click on the Articles/FAQ button on the left, then click on HEIRO/Insulin Resistance Updates.

To order Heiro™, go to the Order Form section.

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